Project information
From classic prognostic markers to clinical applications in selected pharmacogenomic and pharmacoproteomic projects in multiple myeloma and monoclonal gammapathies

Information

This project doesn't include Faculty of Science. It includes Faculty of Medicine. Official project website can be found on muni.cz.

Project Identification

MSM0021622434

Project Period

1/2007 - 12/2013

Investor / Pogramme / Project type

Ministry of Education, Youth and Sports of the CR

Research Intents

MU Faculty or unit

Faculty of Medicine

prof. MUDr. Roman Hájek, CSc.

Keywords

multiple myeloma; proteomics; genomics

Monoclonal gammapathies and multiple myeloma in particular are among the most common and debilitating malignancies in the elderly population. In the last decade, there have been dramatic developments in basic and applied research in the field. New treatments have become available and treatment standards have changed. Treatment results have substantially improved and the probability of 10-year survival increased from 5% to 20% in the last decade. However, the disease is still incurable. The treatment strategy today includes potentially 3-5 regimens administered over a period of 10 to 15 years. There is increased tendency to apply treatment specifically tailored for a subgroup of patients with a well-defined risk and response rate.

Publications

Total number of publications: 314

2011

Vyšetření specifických chromozomových abnormalit u monoklonální gamapatie nejasného významu pomocí interfázní fluorescenční in situ hybridizace

MIKULÁŠOVÁ Aneta KUGLÍK Petr SMETANA Jan GREŠLIKOVÁ Henrieta KUPSKÁ Renata NĚMEC Pavel ZAORALOVÁ Romana BUREŠOVÁ Ivana BARTOŇOVÁ Jana ADAM Zdeněk KLINCOVÁ Mária HÁJEK Roman

Conference abstract

Year: 2011, type: Conference abstract
Waldenströmova makroglobulinémie

ADAM Zdeněk KOŘÍSTEK Zdeněk POUR Luděk

Article in Periodical

Postgraduální medicína, year: 2011, volume: 13, edition: 9

2010

5th Myeloma workshop: Flow cytometry and cytogenetics: Application of flow cytometry and cytogenetics approach in monoclonal gammopathies and multiple myeloma

HÁJEK Roman

Workshop

Year: 2010, type: Workshop
A preliminary study report of T regulatory cells in pre and post treated myeloma patients

MUTHU RAJA Karthick Raja ZAHRADOVÁ Lenka MIKULKOVÁ Zuzana CIBULKA Marek BUREŠOVÁ Ivana KOVÁŘOVÁ Lucie HÁJEK Roman MICHÁLEK Jaroslav

Conference abstract

Year: 2010, type: Conference abstract
An interim study report of CD44 standard molecule and its variant isoform expression in MGUS and MM

MUTHU RAJA Karthick Raja BUREŠOVÁ Ivana KOVÁŘOVÁ Lucie ŠTOSSOVÁ Jana HÁJEK Roman

Conference abstract

Year: 2010, type: Conference abstract
Analýza subpopulací B lymfocytů v periferní krvi zdravých osob

ZARBOCHOVÁ Pavla KOVÁŘOVÁ Lucie SUSKÁ Renata PENKA Miroslav HÁJEK Roman

Conference abstract

Year: 2010, type: Conference abstract
Array CGH in multiple myeloma: Practical notes and our preliminary results

ZAORALOVÁ Romana NĚMEC Pavel SMETANA Jan GREŠLIKOVÁ Henrieta KUGLÍK Petr HÁJEK Roman

Conference abstract

Year: 2010, type: Conference abstract
Assessment of Immune Regulatory and Suppressor Cells in Monoclonal Gammopathies

MUTHU RAJA Karthick Raja KOVÁŘOVÁ Lucie BUREŠOVÁ Ivana ŠTOSSOVÁ Jana HÁJEK Roman MICHÁLEK Jaroslav

Conference abstract

Year: 2010, type: Conference abstract
Association of CD44s and their isoforms with prognostic features of multiple myeloma

MUTHU RAJA Karthick Raja BUREŠOVÁ Ivana KOVÁŘOVÁ Lucie ŠTOSSOVÁ Jana HÁJEK Roman

Conference abstract

Year: 2010, type: Conference abstract
Association of plasma cell phenotype with cytogenetic findings in multiple myeloma

KOVÁŘOVÁ Lucie BUREŠOVÁ Ivana MUTHU RAJA Karthick Raja GREŠLIKOVÁ Henrieta NĚMEC Pavel SMETANA Jan KUPSKÁ Renata PENKA Miroslav KUGLÍK Petr HÁJEK Roman

Conference abstract

Year: 2010, type: Conference abstract