TAME builds upon the recent introduction of interactive VP cases for training in both eViP ePBLnet and Clinical Reasoning in CROESUS. It includes associate partners and bidding partners (in total numbering more than 25 institutions) from all previous projects, and involving applicants from all these previous projects. In many ways these previous projects teach the principle of clinical decision-making. but this project goes to the next level.This project takes the use of VPs one important step further, by targeting the most important factor in clinical education, patient safety, and asks the question how can we best adapt VPs to maximise the possibilities of training against medical error? The process would be to use VPs in later parts of the course, VPs which are specific and more detailed in clinical attachments. The virtual patients should be able to challenge the students’ thought process built on the knowledge acquired during their early years of their degree. They would be constructed to allow students to take wrong decisions, decisions that seem entirely plausible and are usually based on real-world incidents; students would take actions based on those decisions, and experience the consequences of those actions. Pedagogically this project addresses a fundamental issue in clinical management, to safely train learners in making correct decisions, without compromising patient safety and without requiring exposure to every clinical situation or disease the student may need to be familiar with.