Project information
Self-assembly of amphiphilic peptides with helical character
(SAAP)
- Project Identification
- GA14-12598S
- Project Period
- 1/2014 - 12/2016
- Investor / Pogramme / Project type
-
Czech Science Foundation
- Standard Projects
- MU Faculty or unit
- Faculty of Science
In living organisms, a wide variety of peptides self-assemble into a range of structures, which can be vital or
lethal. The proposed project aims at elucidating key conditions and properties of self-assembly of amphiphilic
peptides with prolate shape. The key insight in the self-assembly is rationalization of the dependence of
aggregate morphology on the structure of building blocks. To explore the dependence, we will use computer
simulations with coarse grained models, which are computational affordable and at the same time contain
the essential features of building peptides. The obtained knowledge could provide a valuable information
for development of new peptide based materials, scaffolds, and therapeutics.
Publications
Total number of publications: 15
2018
-
Aggregate Size Dependence of Amyloid Adsorption onto Charged Interfaces
Langmuir, year: 2018, volume: 34, edition: 4, DOI
2017
-
Design of Multivalent Inhibitors for Preventing Cellular Uptake
Scientific Reports, year: 2017, volume: 7, edition: SEP, DOI
-
Self-assembled clusters of patchy rod-like molecules
SOFT MATTER, year: 2017, volume: 13, edition: 41, DOI
2016
-
(GM1) Ganglioside Inhibits beta-Amyloid Oligomerization Induced bySphingomyelin
Angewandte Chemie International Edition, year: 2016, volume: 55, edition: 32, DOI
-
Anomalous Fibril Interaction with Surfaces
Year: 2016, type: Appeared in Conference without Proceedings
-
Influence of ligand distribution on the efficiency of nanoparticle uptake
Year: 2016, type: Appeared in Conference without Proceedings
-
Peptide Features Determining its Translocation and Pore Formation
Year: 2016, type: Appeared in Conference without Proceedings
2015
-
Influence of ligand distribution on nanoparticle uptake effciency
Year: 2015, type: Appeared in Conference without Proceedings
-
Influence of ligand distribution on uptake efficiency
SOFT MATTER, year: 2015, volume: 11, edition: 14, DOI
-
Optimal conditions for opening of membrane pore by amphiphilic peptides
JOURNAL OF CHEMICAL PHYSICS, year: 2015, volume: 143, edition: 24, DOI