Project information
Bezpečná biotechnologie alotransplatovaných hematopoetických kmenových buněk u vybraných solidních a hematologických nádorů jako adoptivní imunoterapie
(NPVII11001)
- Project Identification
- 2B06058
- Project Period
- 7/2006 - 6/2011
- Investor / Pogramme / Project type
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Ministry of Education, Youth and Sports of the CR
- Health and quality of life
- MU Faculty or unit
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Faculty of Medicine
- prof. MUDr. Jaroslav Michálek, Ph.D.
- prof. MUDr. Roman Hájek, CSc.
- RNDr. Libor Hanák, Ph.D.
- RNDr. Radek Horváth, Ph.D.
- Dana Hrušková
- Mgr. Veronika Janečková, Ph.D.
- RNDr. Jiří Jelínek, Ph.D.
- RNDr. Eva Matějková
- Mgr. Klára Mollová
- Mgr. Lucie Říhová, Ph.D.
- Mgr. Jana Smejkalová, Ph.D.
- doc. RNDr. Sabina Ševčíková, Ph.D.
- Mgr. Hana Šváchová, Ph.D.
- Petra Vidláková
- Mgr. Kateřina Vopěnková, Ph.D.
- Cooperating Organization
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Genex CZ, s.r.o.
Safe biotechnology of allotransplated hematopoietic stem cells in selected solid and haematologic tumors as an adoptive immunotherapy
The project focuses on the adoptive immunotherapy using experimental allogeneic hematopoietic stem cell transplantation. It primarily concentrates on finding a safe biotechnology of allogeneic stem cell graft preparation to minimize its unwanted alloreactivity leading often to lethal graft-versus-host reaction, and at the same time to preserve and potentiate its anti-tumor reactivity. Experimental verification of this procedure could lead to a rapid progress in the clinical usage of allogeneic transplantation in oncology and other fields.
Results
Publications
Total number of publications: 82
2010
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New generation of cancer vaccines based on IL-12 producing dendritic cells. Phase II clinical trial in patients with glioblastoma multiforme
Year: 2010, type: Conference abstract
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New generation of interleukin IL-12 producing dendritic cells in cancer
Year: 2010, type: Conference abstract
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Nová generace individualizované vakcíny na bázi dendritických buněk u pacientů s primárním glioblastomem
Year: 2010, type: Conference abstract
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Nová generace vakcín na bázi dendritických buněk – klinická studie pro pacienty s glioblastomem
Year: 2010, type: Conference abstract
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Nové technologie kultivace buněk "WAVE Bioreactor System BASE 2/10EH"
Year: 2010, type: Conference abstract
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Optimized Maturation Cocktail for Clinical Grade Dendritic Cell Vaccination
Year: 2010, type: Appeared in Conference without Proceedings
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Optimizing of bone marrow- and adipose tissue-derived mesenchymal stromal cells manufacturing for clinical trials
Year: 2010, type: Conference abstract
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Optimizing of bone marrow- and adipose tissue-derived mesenchymal stromal cells manufacturing for clinical trials according to GMP guidelines
Year: 2010, type: Conference abstract
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Protinádorová vakcína na bázi dendritických buněk u nemocných s mnohočetným myelomem
Year: 2010, type: Conference abstract
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Příprava mezenchymálních kmenových buněk podle pravidel správné laboratoní praxe pro aplikaci v léčbě nemoci štěpu proti hostiteli a autoimunitních chorob
Year: 2010, type: Conference abstract