Project information
From classic prognostic markers to clinical applications in selected pharmacogenomic and pharmacoproteomic projects in multiple myeloma and monoclonal gammapathies
- Project Identification
- MSM0021622434
- Project Period
- 1/2007 - 12/2013
- Investor / Pogramme / Project type
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Ministry of Education, Youth and Sports of the CR
- Research Intents
- MU Faculty or unit
- Faculty of Medicine
- Keywords
- multiple myeloma; proteomics; genomics
Monoclonal gammapathies and multiple myeloma in particular are among the most common and debilitating malignancies in the elderly population. In the last decade, there have been dramatic developments in basic and applied research in the field. New treatments have become available and treatment standards have changed. Treatment results have substantially improved and the probability of 10-year survival increased from 5% to 20% in the last decade. However, the disease is still incurable. The treatment strategy today includes potentially 3-5 regimens administered over a period of 10 to 15 years. There is increased tendency to apply treatment specifically tailored for a subgroup of patients with a well-defined risk and response rate.
Publications
Total number of publications: 313
2011
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Array-CGH in multiple myeloam research
Year: 2011, type: Conference abstract
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Association of aneuploidy and centrosome abnormalities in myeloma genesis
Year: 2011, type: Conference abstract
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Association of aneuploidy category with centrosome amplification in multiple myeloma
Leukemia & Lymphoma, year: 2011, volume: 52, edition: 10, DOI
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Association of mitotic genes expression and centrosome amplification in multiple myeloma
Year: 2011, type: Conference abstract
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Association Study of Selected Genetic Polymorphisms and Occurrence of Venous Thromboembolism in Patients With Multiple Myeloma Who Were Treated With Thalidomide
Clinical Lymphoma, Myeloma & Leukemia, year: 2011, volume: 11, edition: 5, DOI
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Bortezomib-based regimen induced complete remission of multiple myeloma with regression of osteolytic lesion in femur
Year: 2011, type: Conference abstract
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Castlemanova choroba
Klinická onkologie, year: 2011, volume: 24, edition: 6
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Centrosomal Disruption As Early Event in Myeloma Development
Year: 2011, type: Conference abstract
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Centrosome associated genes in multiple myeloma
Year: 2011, type: Conference abstract
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Clonality assessment in monoclonal gammopathies
Year: 2011, type: Conference abstract