Project information
From classic prognostic markers to clinical applications in selected pharmacogenomic and pharmacoproteomic projects in multiple myeloma and monoclonal gammapathies
- Project Identification
- MSM0021622434
- Project Period
- 1/2007 - 12/2013
- Investor / Pogramme / Project type
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Ministry of Education, Youth and Sports of the CR
- Research Intents
- MU Faculty or unit
- Faculty of Medicine
- Keywords
- multiple myeloma; proteomics; genomics
Monoclonal gammapathies and multiple myeloma in particular are among the most common and debilitating malignancies in the elderly population. In the last decade, there have been dramatic developments in basic and applied research in the field. New treatments have become available and treatment standards have changed. Treatment results have substantially improved and the probability of 10-year survival increased from 5% to 20% in the last decade. However, the disease is still incurable. The treatment strategy today includes potentially 3-5 regimens administered over a period of 10 to 15 years. There is increased tendency to apply treatment specifically tailored for a subgroup of patients with a well-defined risk and response rate.
Publications
Total number of publications: 313
2012
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Analýza moderních prognostických faktorů na buněčné a molekulární úrovni určujících riziko transformace monoklonální gamapatie nejasného významu do mnohočetného myelomu
Klinická biochemie a metabolismus, year: 2012, volume: 20(41), edition: 2
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Biobanka vzorků a její využití pro řadu prediktivních a prognostických analýz mnohočetného myelomu
Year: 2012, type: Conference abstract
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Blokáda receptoru pro interleukin-1 preparátem anakinra vedla u pacienta s Erdheimovou-Chesterovou nemocí k vymizení patologické únavy, k poklesu markerů zánětu a ústupu fibrózy v retroperitoneu – popis případu a přehled literárních údajů
Vnitřní lékařství, year: 2012, volume: 58, edition: 4
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Bone marrow plasma cell separation - validation of separation algorithm
Clinical Chemistry and Laboratory medicine, year: 2012, volume: 50, edition: 6, DOI
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Clinical implication of centrosome amplification and expression of centrosomal functional genes in MM
Year: 2012, type: Conference abstract
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Complex karyotype and translocation t(4;14) define patients with high-risk newly diagnosed multiple myeloma: results of CMG2002 trial
Leukemia & Lymphoma, year: 2012, volume: 53, edition: 5, DOI
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Cytokine analysis in a patient with relapsing Kikuchi-Fujimoto disease
Leukemia & Lymphoma, year: 2012, volume: 53, edition: 4, DOI
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Determining of molecular signature for centrosome abnormalities in multiple myeloma
Year: 2012, type: Conference abstract
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Eozinofilie
Postgraduální medicína, year: 2012, volume: 14, edition: 2
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Evaluation of Immune Suppression in Multiple Myeloma Patients Treated with Lenalidomide Plus Prednisone and Lenalidomide Alone.
Year: 2012, type: Conference abstract