Project information
Nove přístupy pro studium afinitních interakcí založené na kapilární elektroforéze
- Project Identification
- GA19-08358S
- Project Period
- 1/2019 - 6/2022
- Investor / Pogramme / Project type
-
Czech Science Foundation
- Standard Projects
- MU Faculty or unit
- Faculty of Science
Hlavním cílem tohoto projektu je vývoj nových přístupů založených na kapilární elektroforéze pro studium afinitních interakcí plazmatických bílkovin s léčivy charakterizovanými vysokou průchodností, plnou automatizací a nízkou spotřebou vzorku.
Publications
Total number of publications: 29
2022
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Comparison of CE-FA method with conductivity and UV-VIS detection
Advances in chromatography and electrophoresis, Chiranal 2022, year: 2022
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Comparison of mobility shift affinity capillary electrophoresis and capillary electrophoresis frontal analysis for binding constant determination between human serum albumin and small drugs
Electrophoresis, year: 2022, volume: 43, edition: 16-17, DOI
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DETERMINATION OF DRUG-PROTEIN BINDING PARAMETERS BY CE-FA METHOD WITH CONDUCTIVITY AND UV-VIS DETECTION
Year: 2022, type: Conference abstract
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Extending the application potential of capillary electrophoresis/frontal analysis for drug-plasma protein studies by combinating it with mass spectrometry detection
Electrophoresis, year: 2022, volume: 43, edition: 9-10, DOI
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The on-line preconcentration in affinity capillary electrophoresis
Year: 2022, type: Appeared in Conference without Proceedings
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Use of sample preconcentration in CE-FA analyses
Year: 2022, type: Conference abstract
2021
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HODNOCENÍ VAZEBNÝCH SCHOPNOSTÍ IMOBILIZOVANÉHO ALBUMINU NA ZÁKLADĚ MS ANALÝZY
Year: 2021, type: Conference abstract
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Toward an automated workflow for the study of plasma protein-drug interactions based on capillary electrophoresis-frontal analysis combined with in-capillary mixing of interacting partners
Journal of Chromatography A, year: 2021, volume: 1635, edition: January 2021, DOI
2020
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Aldehyde Oxidase Assay by CE: from off-line, on-line up to immobilized enzyme reactor
Journal of Separation Science, year: 2020, volume: 43, edition: 17, DOI
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Analytical approaches for the determination of deferiprone and its iron (III) complex: Investigation of binding affinity based on liquid chromatography-mass spectrometry (LC-ESI/MS) and capillary electrophoresis-frontal analysis (CE/FA)
Microchemical Journal, year: 2020, volume: 154, edition: May 2020, DOI