Project information
Role of S1PR1 in B cell mechanosensitivity

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Project Identification
GA25-16907S
Project Period
1/2025 - 12/2027
Investor / Pogramme / Project type
Czech Science Foundation
MU Faculty or unit
Faculty of Science
Cooperating Organization
Charles University

Mechanobiology of lymphocytes is unexplored emerging field with the significant promise for paradigm-shifting breakthroughs with therapeutic potential. Mechanical activation of adherent cells is long studied. However, tools to study mechanobiology of poorly adherent lymphocytes are available only recently. We take advantage of these new tools and integrate expertise of the two teams to form unique combination of experimental approaches, model systems and know-how to discover how lymphocytes and derived malignant cells respond to mechanical signals.

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Sustainable Development Goal No.  3 – Good health and well-being

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